US10563204B2

Methods of treating cancer harboring hemizygous loss of TP53

University of Texas System

Abstract

Provided herein are methods of treating a patient having a cancer that exhibits (i) a hemizygous loss of the TP53 gene; (ii) a hemizygous loss of the POLR2A gene; and/or (iii) a decreased level of expression of a POLR2A gene product relative to a reference (i.e., control) expression level. The …

University: University of Texas System
Assignee: Board Of Regents, The University Of Texas System
Inventor: Xiongbin LU
Priority date: March 04, 2015
Filing date: March 03, 2016
Grant date: February 18, 2020
Publication date: February 18, 2020
Language: en
PDF source: https://patentimages.storage.googleapis.com/25/82/eb/521c432d94c6df/US10563204B2.pdf
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