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US11919927B2

Prefusion-stabilized hMPV F proteins

University of Texas System

Abstract

Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.

University
University of Texas System
Assignee
Board Of Regents, The University Of Texas System
Inventor
Jason McLellan
Priority date
October 09, 2020
Filing date
April 06, 2023
Grant date
March 05, 2024
Publication date
March 05, 2024
Language
en
Metadata fetched
August 29, 2026 00:31