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US12491188B2

Small molecule PARG inhibitors and methods of use thereof

University of Texas System

Abstract

The present disclosure provides methods of inhibiting PARG in cancer cells, including methods comprising administering a PARG inhibitor that modulates position Tyr795 in PARG. Also provided herein are methods of treating and/or preventing cancer comprising administering a PARG inhibitor. In some …

University
University of Texas System
Assignee
Board Of Regents, The University Of Texas System
Inventor
John A. Tainer
Priority date
March 29, 2019
Filing date
March 27, 2020
Grant date
December 09, 2025
Publication date
December 09, 2025
Language
en
Metadata fetched
August 29, 2026 00:33