Compositions and methods for homoconjugates of antibodies which induce growth …

Abstract

This invention discloses monoclonal antibodies (MAbs) which have little or no signaling activity as monomers become potent anti-tumor agents when they are converted into homoconjugates. The homoconjugates exert anti-growth activity by signaling G 0 /G 1 arrest or apoptosis, depending upon which cell …