Mutations in Kit Confer Imatinib Resistance in Gastrointestinal Stromal Tumors

Abstract

1 . An isolated human KIT polynucleotide comprising a mutation at 1982T, as exemplified by SEQ ID NO:29. 2 . The polynucleotide of claim 1 , further defined as a 1982T→C mutation. 3 . The polynucleotide of claim 1 , further defined as being comprised in a vector. 4 . The polynucleotide of claim 1 ,