US20110110860A1

Modulation of ldl receptor gene expression with double-stranded rnas targeting …

University of Texas Southwestern

Abstract

Gene expression can be selectively regulated by double-stranded “antigene” RNAs that target regions of the low density lipoprotein receptor (LDL-R) promoter, thereby permitting modulation of LDL levels in vivo and subsequent effects on circulating LDL levels.

University: University of Texas Southwestern
Assignee: The Board Of Regents Of The University Of Texas System
Inventor: David R. Corey
Priority date: November 02, 2009
Filing date: November 02, 2010
Publication date: May 12, 2011
Language: en
PDF source: https://patentimages.storage.googleapis.com/8f/85/b6/8d25885896b7ce/US20110110860A1.pdf
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