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US20140349402A1

Car+ t cells genetically modified to eliminate expression of t-cell receptor …

University of Texas System

Abstract

The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising disrupted T cell receptor and/or HLA and comprising a chimeric antigen receptor. In certain embodiments, the compositions are employed allogeneically as universal reagents for “off-the- …

University
University of Texas System
Assignee
Board Of Regents, The University Of Texas System
Inventor
Laurence J. Neil Cooper
Priority date
November 18, 2011
Filing date
November 16, 2012
Publication date
November 27, 2014
Language
en
Metadata fetched
August 29, 2026 00:21