Antibodies with engineered igg fc domains

Abstract

What is claimed is: 1 . A recombinant polypeptide comprising: (a) a chimeric CH2 domain comprising a mammalian IgG Fc CH2 domain having a al loop of a mammalian IgA Fc CH2 domain; and (b) a mammalian IgA Fc CH3 domain. 2 . The polypeptide of claim 1 , further comprising a mammalian IgG Fc CH1 domain.