US20170044496A1

Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy

University of Texas System

Abstract

Disclosed herein is a method for ex vivo expanding tumor-infiltrating lymphocytes for use in adoptive cell therapy (ACT). The method involves culturing tumor fragments from the subject in a culture medium containing IL-2 and a 41BB agonist in an amount effective to expand tumor-infiltrating …

University: University of Texas System
Assignee: Board Of Regents Of The University Of Texas System
Inventor: Amod A. Sarnaik
Priority date: April 10, 2014
Filing date: April 10, 2015
Publication date: February 16, 2017
Language: en
PDF source: https://patentimages.storage.googleapis.com/cb/cd/43/6f2e40240bc930/US20170044496A1.pdf
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