US20220233704A1

Mutants and drug conjugates of r-spondins and use thereof

University of Texas System

Abstract

Recombinant R-spondin (RSPO) polypeptides are provided, such as RSPO that is fused with Fc and/or comprises a conjugated therapeutic agent. Methods for using such polypeptides, for example in treating cancer are also provided.

University: University of Texas System
Assignee: The Board Of Regents Of The University Of Texas System
Inventor: Qingyun J. LIU
Priority date: January 28, 2021
Filing date: January 27, 2022
Publication date: July 28, 2022
Language: en
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