US20250127885A1
University of Texas System
Recombinant antibodies are provided that comprise engineered human IgG1 Fc domains that have reduced affinity for viral FcγRs, such as HCMV gp34 and gp68, as compared to a wild-type human IgG1 Fc domain. The engineered human IgG1 Fc domains have equivalent affinity for CD16A and FcRn as compared …