US20250188186A1
University of Texas System
Recombinant polypeptides are provided that comprise pH-selective mammalian IgG1 Fc domains that selectively binds to FcγRIIIa in an acidic environment. The pH-selective mammalian IgG1 Fc domain has reduced affinity for FcγRIIIa at neutral pH as compared to a wild-type mammalian IgG1 Fc domain …