US20250221964A1

Substituted Isoxazoles as Selective Nav1.7 Inhibitors for Pain Treatment and …

University of Texas System

Abstract

Tri-substituted isoxazole compounds and compound synthesis is disclosed. Tri-substituted isoxazole compounds having sodium gate channel Nav7 selectivity that are tunable for selectivity over Nav1.5. In particular, structure-activity relationship (SAR) studies demonstrated that subtype selectivity …

University: University of Texas System
Assignee: Board Of Regents, The University Of Texas System
Inventor: Doug Franz
Priority date: March 13, 2020
Filing date: March 12, 2021
Publication date: July 10, 2025
Language: en
PDF source: https://patentimages.storage.googleapis.com/fa/3d/47/79ca0b9aadf912/US20250221964A1.pdf
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