Mapping metabolite- and metal ion-protein interactomes using functional dna- …

Abstract

Provided herein are methods of detecting macromolecule (e.g., proteins or nucleic acids) interactors in the vicinity of a metabolite or metal ion pool in a cell. The methods may comprise DNAzyme-and aptamer-based proximity labeling identification (DAP-ID) to identify macromolecules (e.g., proteins …