Peptide antagonists of substance P

Abstract

What is claimed: 1. [D-Arg 1 ,D-Trp 7 ,D-Trp 9 ,Leu 11 ]-Sp. 2. [D-Phe 5 ,D-Trp 7 ,D-Trp 9 ,Leu 11 ]-SP 5-1l . 3. Substance P having amino acid substitutions at one or more of positions 1, 2, 5, 7, 9, or 11, wherein the amino acid substitution at position 1 is D-Arg; position 2 is D-Pro; position 5 is D-Phe;