Activation of latent transforming growth factor β by matrix vesicles

Abstract

A latent growth factor such as transforming growth factor beta (TGFβ) is converted to active form by matrix vesicles or an extract from matrix vesicles. The matrix vesicles may be stimulated with a Regulator of Enhancing Factor (REF) such as 1,25-dihydroxy vitamin D (1,25-(OH) 2 D 3 ) or steroid …