US6593306B1

Methods for modulation and inhibition of telomerase

University of Texas System

Abstract

It was found that normal human stem cells produce a regulated non-processive telomerase activity, while cancer cells produce a processive telomerase activity. Nucleotide analogs, such as 7-deaza-2'-deoxyquanosine-5'-triphosphate (7-deaza-dGTP) were found to be substrates for processive telomerase …

University: University of Texas System
Assignee: Board Of Regents, The University Of Texas Systems
Inventor: Shih-Fong Chen
Priority date: July 06, 1995
Filing date: December 21, 1999
Grant date: July 15, 2003
Publication date: July 15, 2003
Language: en
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