Methods and compositions relating to HDAC 4 and 5 regulation of cardiac gene …

Abstract

What is claimed is: 1. A method for identifying a candidate inhibitor of cardiac hypertrophy comprising: (a) providing an enzyme preparation comprising an HDAC 4 or HDAC 5 enzyme; (b) contacting the enzyme preparation with a test substance; (c) determining HDAC 4 or HDAC 5 MEF-2 binding activity;