US7029861B1

LPS-response gene compositions and methods

University of Texas Southwestern

Abstract

The present invention describes a mutant TLR-4 in mice that does not recognize endotoxin and therefore does not stimulate the secretion of TNF from macrophages. Methods of detecting the mutation are provided; as are methods screening for drugs that may stimulate TNF production. Finally methods of …

University: University of Texas Southwestern
Assignee: Board Of Regents, The University Of Texas System
Inventor: Bruce A. Beutler
Priority date: September 15, 1998
Filing date: September 15, 1999
Grant date: April 18, 2006
Publication date: April 18, 2006
Language: en
PDF source: https://patentimages.storage.googleapis.com/0f/68/95/71c2492c6990e7/US7029861.pdf
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