US7303887B2

Mule: Mcl-1 ubiquitination ligase E3

University of Texas System

Abstract

A HECT-domain containing E3 ubiquitin ligase that mediates the polyubiquitination of Mcl-1, named Mule for Mcl-1 ubiquitin ligase E3, is described. Methods and compositions for modulating functional interaction between Mcl-1 and Mule protein and Mcl-1 mediated apoptosis are described. Diagnostic …

University: University of Texas System
Assignee: Board Of Regents, The University Of Texas System
Inventor: Xiaodong Wang
Priority date: May 18, 2005
Filing date: May 18, 2005
Grant date: December 04, 2007
Publication date: December 04, 2007
Language: en
PDF source: https://patentimages.storage.googleapis.com/f2/07/11/1437dc11216735/US7303887.pdf
Metadata fetched: August 29, 2026 00:18