US8481507B2

Micro-RNAs that control myosin expression and myofiber identity

University of Texas System

Abstract

The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber genes in the treatment of musculoskeletal …

University: University of Texas System
Assignee: The Board Of Regents, The University Of Texas System
Inventor: Eric Olson
Priority date: July 31, 2007
Filing date: July 31, 2008
Grant date: July 09, 2013
Publication date: July 09, 2013
Language: en
PDF source: https://patentimages.storage.googleapis.com/f3/7e/6b/4d3c9b62410cef/US8481507.pdf
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