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US8658614B2

Aptamer-containing compositions and methods for targeting E-selectin

University of Texas System

Abstract

An isolated nucleic acid molecule that selectively binds to an E-selectin protein comprises a contiguous 29-30 nucleotide sequence that includes at least one monothiophosphate or a dithiophosphate modified nucleotide. Also disclosed are methods of inhibiting an E-selectin mediated interaction with …

University
University of Texas System
Assignee
The University of Texas Health Science Center
Inventor
David G. Gorenstein
Priority date
August 13, 2010
Filing date
August 15, 2011
Grant date
February 25, 2014
Publication date
February 25, 2014
Language
en
Metadata fetched
August 29, 2026 00:22