Sythesis of P-chiral compounds

Abstract

Shown is the preparation and subsequent elaboration of P-chiral compounds that can be used as a building block for many P-chiral ligands used, for example, in asymmetric catalytic reactions. Specifically, a synthesis is shown for RP(O)(OR*)CH 2 OH, with R=H, Ph, aryl, alkyl, and R*=menthol (and …