US8962588B2

Micro-RNAS that control myosin expression and myofiber identity

University of Texas System

Abstract

The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber genes in the treatment of musculoskeletal …

University: University of Texas System
Assignee: The Board Of Regents, The University Of Texas System
Inventor: Eric N. Olson
Priority date: July 31, 2007
Filing date: March 12, 2013
Grant date: February 24, 2015
Publication date: February 24, 2015
Language: en
PDF source: https://patentimages.storage.googleapis.com/5f/bb/e2/d392da25cd1fac/US8962588.pdf
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