US9144605B2

Recombinant rift valley fever virus encoding a dominant-negative inhibitor of …

University of Texas System

Abstract

Certain embodiments of the invention are directed to methods and compositions comprising a Rift Valley fever virus (RVFV) wherein a heterologous nucleic acid encoding a dsRNA-dependent protein kinase (PKR) inhibitor is inserted into the NSs region of the virus.

University: University of Texas System
Assignee: The Board Of Regents Of The University Of Texas System
Inventor: Tetsuro Ikegami
Priority date: February 14, 2012
Filing date: February 14, 2013
Grant date: September 29, 2015
Publication date: September 29, 2015
Language: en
PDF source: https://patentimages.storage.googleapis.com/3d/cf/be/18a156d294d320/US9144605.pdf
Metadata fetched: August 29, 2026 00:23