US9216983B2

Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity

University of Texas System

Abstract

Compounds according to Formula I, Formula II, Formula III, Formula V, Formula VI, or to Formula VII, and pharmaceutical compositions of compounds that conform to Formula IV or Formula VIII: where R 1 through R 33 are prescribed, selectively inhibit P. falciparum dihydroorotate dehydrogenase.

University: University of Texas System
Assignee: Board Of Regents, University Of Texas System
Inventor: Margaret Phillips
Priority date: December 21, 2007
Filing date: December 19, 2008
Grant date: December 22, 2015
Publication date: December 22, 2015
Language: en
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